Welcome to Alexandrov lab
Identification of Disease-Associated Human RNA Pathways
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Our lab identifies and studies components of disease-associated human pathways of RNA biogenesis, regulation, and surveillance.
We extensively use biochemical approaches, high-throughput forward genetics, functional genomics, CRISPR-based mutagenesis of the human genome, and fluorescence-activated cell sorting (FACS). We focus on RNA pathways that play critical roles in (a) cancer and (b) genetic diseases that arise from mutations introducing a premature termination codon. Among cancer-associated human RNA pathways, we focus on regulation of the human nuclear long non-coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1). |
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Our latest:
- April 2026: Congratulations to Monireh and Jerry on their outstanding work! The manuscript describing the discovery of the human RMPPc pathway is accepted in principle by Nature Communications. This is the second major Nature Communications paper first-authored by graduate students Monireh Panah and Jerry Che.
- April 2026: Monireh, Bhoomi, and Jerry presented their latest research at the Regulatory and Non-Coding RNAs conference at Cold Spring Harbor.
- March 2026: Bhoomi, Jerry, and Monireh submitted a manuscript reporting the assembly of tens-of-trillions-scale libraries for genomic applications.
- December 2025: Jerry won the Outstanding Graduate in Discovery Award: Jerry Che.
- November 2025: Monireh's discovery of the RMPPc pathway received Best Poster Award at the UC Riverside RNA Symposium: UCRiverside.
- August 2025: Monireh and Jerry presented at the Eukaryotic mRNA Processing Meeting at CSHL: mRNA CSHL.
- June 2025: Jerry's RNase MRP (RMP24 and RMP64) paper published in Cell Reports.
- May 2025: Jerry and Monireh's MALAT1-Mirror paper published in Nature Communications.
- May 2025: Our patent application, in which Jerry, Bhoomi, and Monireh are Inventors, posted on Google Patents.
- May 2025: Jerry, Monireh, and Bhoomi presented at the RNA Society Meeting in San Diego (Jerry presented a plenary talk): RNA 2025 San Diego.
- January 19, 2025: Jerry's preprint reporting the discovery of two new RNase MRP components, RMP24 and RMP64, posted on bioRxiv.
- April 2026: Monireh, Bhoomi, and Jerry presented their latest research at the Regulatory and Non-Coding RNAs conference at Cold Spring Harbor.
- March 2026: Bhoomi, Jerry, and Monireh submitted a manuscript reporting the assembly of tens-of-trillions-scale libraries for genomic applications.
- December 2025: Jerry won the Outstanding Graduate in Discovery Award: Jerry Che.
- November 2025: Monireh's discovery of the RMPPc pathway received Best Poster Award at the UC Riverside RNA Symposium: UCRiverside.
- August 2025: Monireh and Jerry presented at the Eukaryotic mRNA Processing Meeting at CSHL: mRNA CSHL.
- June 2025: Jerry's RNase MRP (RMP24 and RMP64) paper published in Cell Reports.
- May 2025: Jerry and Monireh's MALAT1-Mirror paper published in Nature Communications.
- May 2025: Our patent application, in which Jerry, Bhoomi, and Monireh are Inventors, posted on Google Patents.
- May 2025: Jerry, Monireh, and Bhoomi presented at the RNA Society Meeting in San Diego (Jerry presented a plenary talk): RNA 2025 San Diego.
- January 19, 2025: Jerry's preprint reporting the discovery of two new RNase MRP components, RMP24 and RMP64, posted on bioRxiv.
Our Addgene collection: www.addgene.org/Andrei_Alexandrov/
Contact:
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Andrei Alexandrov, PhD
Assistant Professor of Genetics and Biochemistry Clemson University's Institute for Human Genetics Self Regional Hall, Rm 134 114 Gregor Mendel Circle Greenwood, SC 29646 (203)-848-9835 [email protected] www.alexandrovlab.com/ |
Genetics & Biochemistry at Clemson University: https://www.clemson.edu/science/academics/departments/genbio/about/profiles/andreia
Clemson University's Institute for Human Genetics: scienceweb.clemson.edu/chg/people/
Clemson University's Institute for Human Genetics: scienceweb.clemson.edu/chg/people/
