Welcome to Alexandrov lab
Identification of Disease-Associated Human RNA Pathways
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Our lab identifies and studies components of disease-associated human pathways of RNA biogenesis, regulation, and surveillance.
We extensively use biochemical approaches, high-throughput forward genetics, functional genomics, CRISPR-based mutagenesis of the human genome, and fluorescence-activated cell sorting (FACS). We focus on RNA pathways that play critical roles in (a) cancer and (b) genetic diseases that arise from mutations introducing a premature termination codon. Among cancer-associated human RNA pathways, we focus on regulation of the human nuclear long non-coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1). |
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Our latest:
- January 2026: Bhoomi, Jerry, and Monireh's manuscript reporting the assembly of tens-of-trillions-scale libraries for genomic applications is submitted to Nature Methods.
- December 2025: Monireh and Jerry's manuscript describing the identification of the RMPPc pathway went out for review at Nature Communications (currently in revision).
- December 2025: Jerry won the Outstanding Graduate in Discovery Award: Jerry Che.
- November 2025: Monireh's discovery of the RMPPc pathway received Best Poster Award at the UC Riverside RNA Symposium: UCRiverside.
- August 2025: Monireh and Jerry presented at the Eukaryotic mRNA Processing Meeting at CSHL: mRNA CSHL.
- June 2025: Jerry's RNase MRP (RMP24 and RMP64) paper published in Cell Reports.
- May 2025: Jerry and Monireh's MALAT1-Mirror paper published in Nature Communications.
- May 2025: Our patent application, in which Jerry, Bhoomi, and Monireh are Inventors, posted on Google Patents.
- May 2025: Jerry, Monireh, and Bhoomi presented at the RNA Society Meeting in San Diego (Jerry presented a plenary talk): RNA 2025 San Diego.
- January 19, 2025: Jerry's preprint reporting the discovery of two new RNase MRP components, RMP24 and RMP64, posted on bioRxiv.
- December 2025: Monireh and Jerry's manuscript describing the identification of the RMPPc pathway went out for review at Nature Communications (currently in revision).
- December 2025: Jerry won the Outstanding Graduate in Discovery Award: Jerry Che.
- November 2025: Monireh's discovery of the RMPPc pathway received Best Poster Award at the UC Riverside RNA Symposium: UCRiverside.
- August 2025: Monireh and Jerry presented at the Eukaryotic mRNA Processing Meeting at CSHL: mRNA CSHL.
- June 2025: Jerry's RNase MRP (RMP24 and RMP64) paper published in Cell Reports.
- May 2025: Jerry and Monireh's MALAT1-Mirror paper published in Nature Communications.
- May 2025: Our patent application, in which Jerry, Bhoomi, and Monireh are Inventors, posted on Google Patents.
- May 2025: Jerry, Monireh, and Bhoomi presented at the RNA Society Meeting in San Diego (Jerry presented a plenary talk): RNA 2025 San Diego.
- January 19, 2025: Jerry's preprint reporting the discovery of two new RNase MRP components, RMP24 and RMP64, posted on bioRxiv.
Our Addgene collection: www.addgene.org/Andrei_Alexandrov/
Contact:
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Andrei Alexandrov, PhD
Assistant Professor of Genetics and Biochemistry Clemson University's Institute for Human Genetics Self Regional Hall, Rm 134 114 Gregor Mendel Circle Greenwood, SC 29646 (203)-848-9835 [email protected] www.alexandrovlab.com/ |
Genetics & Biochemistry at Clemson University: https://www.clemson.edu/science/academics/departments/genbio/about/profiles/andreia
Clemson University's Institute for Human Genetics: scienceweb.clemson.edu/chg/people/
Clemson University's Institute for Human Genetics: scienceweb.clemson.edu/chg/people/
