Welcome to Alexandrov lab

Identification of Disease-Associated Human RNA Pathways 

    We are state of the art equipped lab in the Clemson Center for Human Genetics (https://scienceweb.clemson.edu/chg/). We use forward genetics to identify and study disease-associated human pathways of RNA biogenesis, regulation, and surveillance.
     To allow forward genetic interrogation of RNA pathways, we develop ultra high-throughput methods that employ CRISPR-based mutagenesis of the human genome and FACS (fluorescence-activated cell sorting).  
    The RNA pathways we are focusing on play critical roles in (a) cancer and (b) genetic diseases that arise from mutations resulting in a premature termination codon (PTC). 
    Among cancer-associated human RNA pathways, we are mainly focusing on those regulating levels of the human nuclear long non-coding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1). 
    Nonsense-mediated degradation (NMD) pathway that degrades mRNA carrying a premature termination codons (PTC) is the second major pathway of our interest.

Opportunities:
- We have research assistantship (RA) opportunities for highly motivated graduate students wishing to conduct cutting-edge research in our lab.
- We have an open position of a research technician and summer research opportunities for undergraduate students.
- Highly motivated undergraduate students wishing to gain fist-hand experience in CRISPR, FACS, mutational screening of the human genome, and work with human cell lines are also welcome.
To inquire, please email Andrei Alexandrov (andreia@clemson.edu).

​Contact:
Andrei Alexandrov, PhD
​Assistant Professor of Genetics and Biochemistry
Clemson University 
​Center for Human Genetics
Self Regional Hall, Rm 134
114 Gregor Mendel Circle
Greenwood, SC 29646
(203)-848-9835
andreia@clemson.edu
CHG: https://scienceweb.clemson.edu/chg/
​Lab: https://www.alexandrovlab.com/